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Vicodin is a combination medication that contains two main ingredients: hydrocodone, an opioid analgesic, and acetaminophen, a non-opioid pain reliever and fever reducer. The combination of these two components creates a potent pain-relieving effect, making Vicodin commonly prescribed for the management of moderate to severe pain. Hydrocodone in Vicodin binds to opioid receptors in the brain and spinal cord, altering the perception of pain, while acetaminophen enhances the overall pain-relieving effects and helps reduce fever.

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